12 Haziran 2012 Salı

Korlym: New drug to treat Cushing's Disease

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I know several folks who have recently started taking the new FDA-approved drug, Korlym, to treat Cushing's Disease.  Korlym is a new name for the "old" drug mifepristone and was developed by Corcept Therapeutics Incorporated. 
Korlym blocks the activity of cortisol and is proven to reduce high blood sugar (hyperglycemia), a key symptom of Cushing's. Korlym has a unique way of working. Instead of reducing cortisol levels, it blocks the action of cortisol, thus preventing the effects of excess cortisol.1
Korlym has many side effects and cannot be taken by everyone.  Once the patient stops taking Korlym, she will continue to have Cushing's.  The biologic half-life of Korlym is approximately 85 hours.  If a patient suffers adrenal insufficiency or crisis, massive amounts of hydrocortisone or dexamethasone are needed to alleviate these and will have to be continued for the duration of the drug in his system.

To follow a patient who has just started taking Korlym, you will find her blog here:  Cushing's Disease

6 Haziran 2012 Çarşamba

Korlym: New drug to treat Cushing's Disease

To contact us Click HERE
I know several folks who have recently started taking the new FDA-approved drug, Korlym, to treat Cushing's Disease.  Korlym is a new name for the "old" drug mifepristone and was developed by Corcept Therapeutics Incorporated. 
Korlym blocks the activity of cortisol and is proven to reduce high blood sugar (hyperglycemia), a key symptom of Cushing's. Korlym has a unique way of working. Instead of reducing cortisol levels, it blocks the action of cortisol, thus preventing the effects of excess cortisol.1
Korlym has many side effects and cannot be taken by everyone.  Once the patient stops taking Korlym, she will continue to have Cushing's.  The biologic half-life of Korlym is approximately 85 hours.  If a patient suffers adrenal insufficiency or crisis, massive amounts of hydrocortisone or dexamethasone are needed to alleviate these and will have to be continued for the duration of the drug in his system.

To follow a patient who has just started taking Korlym, you will find her blog here:  Cushing's Disease

Ample Amount Of Entertainment With Apple iPhone 4G Accessories

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The next Cohort iPhone 4G has recent up-to-the-minute and facial appearance completely altered from pardon? Came already. Innovative facial appearance Take in front facing videocassette chat camera, camera flare, micro SIM in its place of Usual SIM and a somewhat better battery in favor of Improved and long lasting Presentation. The iPhone has 5 megapixel camera and tape recording up-to 30 frames for every flash plus it additionally has LED spark and photo and tape geo-tagging. The screen size is 3.5 inch with 960 by 640-pixel resolution on 326ppi. 4G take in up-to-the-minute wireless and cellular know-how like GSM/EDGE and Blutooth 2.1 and all that. IPhone 4G has nearly Exhilarating accessories that Composes it Extra Tendy and Creative. Apple iphone 4G accessories include:


Apple iPhone 4G Plantronics Discovery 925 Bluetooth Hands-Free Headset:

The Plantronics Discovery 925 Bluetooth Hands-Free Headset gives you numerous variety and unlimited presentation. Its Unique facial appearance such as adaptive din cancelling know-how Condenses background voice according to conversation and atmosphere, AudioIQ know-how and up-to 5 hours gossip period or 7 days support from only a single charge.

Apple iPhone 4G Sandisk 16GB MicroSDHC Memory Card:

The MicroSDHC recollection card with 16GB recollection break opens doors in support of Abundant amount of entertainment with harmony, videos, movies and pictures plus more and more data such as contacts, store associated to presentation and all that. The microSDHC furthermore has 5 year incomplete warranty by Sandisk plus compatible with sharp tempo USB 2.0 move toll.

Apple iPhone 4G Screen Protectors:

Keep your 4G screen protected from scratches, fingerprint and dust. Easy fit on iPhone 4G and at hand is rejection need of heartless already applying screen. Screen proctors offer on the spot protection and long lasting protection to your phone 24/7.

Apple iPhone 4G Bracketron transportable Cup-It Universal Cup Holder Mount - Original:

A unlimited part of the pack of know-how shielding your phone from wear and tear and giving you most comfort while driving and looking on your phone especially after at hand is a need of GPS from your phone. The robust loosen streak and 360 degree rotating gives you comfort of viewing your phone from multiple instructions.

Apple iPhone 4G Silver Cell Phone and PDA Holder Windshield Mount:

Easily mounts to a few vehicle’s windshield and amendable streak and rotating head in support of your convenience while driving plus only one-button to facilitate releases your mobile quickly. The device gives you a custom fit and prevents your phone from scratches.

Apple iPhone 4G Cell Phone Antenna and Repeater Signal Booster Car Mount:

The Apple iPhone 4G Cell Phone Antenna and Repeater Signal Booster Car Mount moving parts brilliantly with your iPhone 4G civilizing its call quality. The repeater amplifies you iPhone 4G signals and ensures to facilitate you don’t obtain problems in dropping calls. The Antenna fits without a glitch on your car and moving parts fine with 6dBi, 800, 900, 1800, 1900 MHz.

Apple iPhone 4G Cases:

IPhone 4G gear gives a another look and variety to your mobile and protects it from scratches, fingerprints, dents and dings and all that. The Apple iPhone 4G gear are free in altered insignia giving a another level approach on your phone.
By: Ronnie Williams

Pituitary Tumor Surgery: Protect Yourself From Malpractice

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As a trial lawyer, I have handled numerous medical malpractice cases over the years, and it has required that I learn a great deal of medicine. While some of it is fascinating, some is downright frightening. In fact, I now subscribe to the belief that the only type of “minor surgery” is when they are operating on someone else….other than me or my family! Pituitary tumor surgery is certainly no exception.

The pituitary is an endocrine gland located in a small cavity at the base of the brain. Pituitary tumors are abnormal growths that develop in the gland and are usually benign (non-cancerous). Nevertheless, as they grow in size the tumors can cause problems such as vision loss, double vision, drooping of the eyelids, severe headaches, and hormone imbalance which can cause lightheadedness, excessive thirst, fatigue and cold intolerance. One of the most common forms of treatment for pituitary tumors is surgical removal. Most can be removed transsphenoidally (through the sphenoid sinus cavities located behind the nose).

Others can be removed transcranially (through the upper part of the skull). While it may be hard to believe from looking at this diagram, generally these surgeries are relatively safe when performed by experienced surgeons. For this reason, you should always make sure your team of surgeons (surgeries are typically performed by an ear, nose and throat surgeon together with a neurosurgeon (brain surgeon)) have received specialized training and perform numerous pituitary tumor surgeries each year.

Like all surgeries, pituitary tumor surgery is accompanied by the risk of complication. Because the pituitary gland is located next to the skull base, it is extremely important for surgeons to maintain the proper angle of approach and an awareness of surrounding anatomy. Serious complications can occur if the wrong angle of approach is utilized. For example, if the surgeon dissects above or beyond the tumor mass, he can penetrate the skull base and cause damage to the brain and surrounding arteries.

While some injuries cannot be avoided, others occur simply because the surgeon(s) was negligent (failed to exercise that degree of skill and care generally required of surgeons under similar circumstances). Injuries which can occur include:

• Damage to the carotid arteries leading to stroke or death

• Permanent loss of vision

• Spinal fluid leak or spinal cord damage

• Infection and/or meningitis

• Brain injury or brain damage

So what should you do to protect yourself against a bad outcome? First, make sure your surgeons have lots of experience. In this day and age there are tons of resources available on the web to help you find the best team of surgeons. Read on-line articles about the surgery and then note who authored them. Contact the author’s office and get a recommendation. You will be surprised how helpful their staff can be. The author himself may even be willing to see you or make a referral. Most experienced surgeons—experts—will be in large metropolitan areas and/or teaching hospitals. This is especially true of accomplished neurosurgeons. To find the best you will probably have to travel, but it is worth the extra money. As I said, they are operating in the middle of your head, this is not “minor surgery” and you want the best.

Once your surgeon is selected, educate yourself about the procedure so you can ask intelligent questions and understand what the doctor tells you. Finally, ask your surgeon directly about his or her level of expertise. How many pituitary tumor surgeries has he or she performed in the last couple of years. If it is a teaching hospital where they train residents, make sure the surgeon you consult is the one who will actually perform the procedure. Tell them directly that you do not want anyone else operating on you. While it is hard to believe, sometimes people travel halfway across the country to see a particular specialist only to have a resident operate on them instead once they are asleep. It really happens. Experience matters in pituitary tumor surgery so insist on the best. Hopefully, if you follow this advice you will enjoy a speedy recovery and will not need suggestions on how to find an experienced malpractice lawyer!
by: Thomas R. Burnside

Yankees' Rivera blows save

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Carlos Peña hit an early grand slam off CC Sabathia, then completed a ninth-inning comeback with an RBI single off closer Mariano Rivera to give host Tampa Bay a 7-6 victory over the New York Yankees on Friday. Evan Longoria also homered for the Rays, and New York's Raul Ibanez hit a three-run homer.
Diamondbacks 5, Giants 4 — Chris Young and Paul Goldschmidt hit first-inning home runs and Ryan Roberts broke a tie with a two-run double in the sixth as host Arizona beat Tim Lincecum (0-1) for the fourth straight time.

Orioles 4, Twins 2 — Jake Arrieta allowed two hits with four strike outs and two walks in seven scoreless innings and Nick Markakis homered and drove in three runs as victorious Baltimore marked the 20th anniversary of the opening of Camden Yards.
Rangers 3, White Sox 2 — After failing to reach a long-term deal before his deadline, Ian Kinsler homered, doubled and scored twice as host Texas spoiled the managerial debut of Robin Ventura, who before the game had his first meeting with Nolan Ryan since charging the mound 19 seasons earlier against the Hall of Fame pitcher. Ryan is president, CEO and part-owner of the Rangers.
Rockies 5, Astros 3 — Eric Young scored the go-ahead run on an error in the eighth and Troy Tulowitzki homered in the ninth to lift visiting Colorado.
Notebook
Injury updates — Houston shortstop Jed Lowrie (right thumb) went on the DL. ... Kendrys Morales returned to the Los Angeles Angels after missing nearly two years with a broken left ankle suffered celebrating a game-ending grand slam.
Associated Press

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Amanda Bynes arrested on suspicion of DUI in WeHo

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Amanda Bynes was arrested early Friday morning on suspicion of DUI in West Hollywood after she allegedly hit the rear corner of a sheriff's cruiser while trying to pass it.
That is most certainly not "What a Girl Wants."
In the wake of her 3 a.m. arrest, the "She's the Man" actress and former Nickelodeon star was in custody at the West Hollywood Sheriff's Station, L.A. Now reported, before being released around 10:30 a.m. on $5,000 bail. She was arrested near the intersection of Robertson and Santa Monica boulevards.
PHOTOS: Celebrity mug shots

Bynes has been hitting the Hollywood party scene recently, according to TMZ, which had late-night St. Patrick's Day footage taken outside a club where the photographer cautioned the valet against letting her drive — a caution that was ignored as the actress left in her Range Rover with a friend.
Yes, we did say "actress," though it's hard to tell sometimes: Bynes retired from acting for a whole month in the summer of 2010, only to announce her return via Twitter a bit ahead of the release of "Easy A," which she appeared in with Emma Stone. That September 2010 release is still her most recent.
And about that hair in the mug shot above — it would appear to be the latter days of lilac, as Bynes broadcast a month ago on Twitter, "Did I mention I dyed my hair lilac?!?!?! LILAC !!!!!!!!"
Just when we were really starting to miss Lindsay
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30 Mayıs 2012 Çarşamba

Day Nineteen, Cushing's Awareness Challenge

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In Day 10 on April 10, 2012, I wrote about how we got the Cushing's colors of blue and yellow.  This post is going to be about the first Cushing's ribbons.

 

I was on vacation  in September, 2001 when SuziQ called me to let me know that we had had our first Cushie casualty (that we knew about).

On the message boards, Lorrie wrote: Our dear friend, Janice died this past Tuesday, September 4, 2001. I received an IM from her best friend Janine, tonight. Janine had been reading the boards, as Janice had told her about this site, and she came upon my name and decided to IM me. I am grateful that she did. She said that she knew that Janice would want all of us to know that she didn't just stop posting.

For all of the newcomers to the board that did not know Janice, she was a very caring individual. She always had something positive to say. Janice was 36 years old, was married and had no children. She had a miscarriage in December and began to have symptoms of Cushing's during that pregnancy. After the pregnancy, she continued to have symptoms. When discussing this with her doctor, she was told that her symptoms were just related to her D&C. She did not buy this and continued until she received the accurate diagnosis of Cushing's Syndrome (adrenal) in March of 2001. Tragically, Janice's tumor was cancerous, a very rare form of Cushing's.

Janice then had her tumor and adrenal gland removed by open adrenalectomy, a few months ago. She then began chemotherapy. She was very brave through this even though she experienced severe side effects, including weakness and dizziness. She continued to post on this board at times and even though she was going through so much, she continued with a positive attitude. She even gave me a referral to a doctor a few weeks ago. She was my inspiration. Whenever I thought I had it bad, I thought of what she was dealing with, and I gained more perspective.

Janice was having difficulty with low potassium levels and difficulty breathing. She was admitted to the hospital, a CT scan was done and showed tumor metastasis to the lungs. She then was begun on a more aggressive regimen of chemo. She was discharged and apparently seemed to be doing well.

The potassium then began to drop again, she spiked a temp and she was again admitted to the hospital. She improved and was set to be discharged and then she threw a blood clot into her lungs. She was required to be put on a ventilator. She apparently was at high risk for a heart attack. Her husband did not want her to suffer anymore and did not want her to suffer the pain of a heart attack and so chose for the doctors to discontinue the ventilator on Tuesday. She died shortly thereafter.

Janice was our friend. She was a Cushie sister. I will always remember her. Janine asked me to let her know when we get the Cushing's ribbons made as she and the rest of Janice's family would like to wear them in her memory. She said that Janice would want to do anything she could to make others more aware of Cushing's.

The image at the top of the page shows the first blue and yellow ribbon which were worn at Janice's funeral.  When we had our "official ribbons" made, we sent several to Janice's family.

Janice was the first of us to die but there have been more, way too many more, over the years.  I'll write a bit more about that on Day 21.